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Exogenous Ketones

What are Exogenous Ketones

What are Exogenous Ketones


Before we jump into exogenous ketones, let’s do a quick review of what indigenous ketones (Ketone Bodies) are. Ketones that are naturally produced by the body include acetoacetate, beta-hydroxybutyrate, and acetone.

A person living a normal healthy lifestyle will not naturally enter ketosis unless they have type 1 diabetes (diabetic ketoacidosis – the body produces excess ketones), during excessive alcohol consumption, and during times of fasting. When the body runs out of it’s the natural supply of energy (glucose), it has to rely on ketone bodies instead.

Deliberate Ketosis – the Keto Diet:

Individuals who severely limit or even eliminate their carbohydrate intake can force the body to enter ketosis. Deliberately induced ketosis can serve as a treatment for conditions, such as intractable epilepsy and diabetes.

Ketogenic diets help with:

  • Weight loss
  • Increased HDL cholesterol levels
  • Reduced blood glucose levels

How Does Ketosis Induce Weight Loss?

Exogenous ketone bodies are breakdown products of fatty acids, so essentially, by forcing the body into ketosis, the body is forced to burn fat instead of carbohydrates (glucose) for energy. If the body is solely relying on fat for energy, the body will lose fat at a more rapid pace.

What are Exogenous Ketones?

Exogenouss ketone supplements


The word exogenous means external, so exogenous ketone supplements are forms of the naturally occurring ketone beta-hydroxybutyrate.
The idea behind taking exogenous ketones is in addition to adhering to a high-fat, low-carb diet is to amplify the rate of ketosis in the body. In a study published in “Frontiers in Physiology,” the authors concluded that taking supplemental Ketones to help achieve a state of ketosis was ”
 a practical, efficacious way” to reach ketosis.

Dangers of Exogenous Ketones

Is the use of Exogenous Ketones in the Keto Diet Safe?

When considering using diatary ketones to augment a keto diet you need to consider some of the potential health complications that can occur. Here is a list of potential problems that you can develop:

  • Rhabdomyolysis ( severe pathologicl muscle breakdown)
  • Kidney Stones
  • Gout Typically people adhering to strict keto-diet rules will increase their intake of meat. Increased intake of red meat can cause a build-up of uric acid in the blood, which is ultimately filtered by the kidneys, causing kidney stones. Excess uric acid can also deposit and build up in the joints, causing gouty arthritis.
  • Dehydration and Nutritional Deficiency When eliminating any one specific item from the diet, this disturbs the balance of electrolytes and can result in dehydration and or nutritional deficiencies.
  • Increased Risk for High Cholesterol and Heart Disease Increased intake of fat is a risk factor for increased levels of cholesterol. High cholesterol is a risk factor for coronary artery disease and atherosclerosis.
Updated on February 17, 2019

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